Dynamic self-organization (DSO), or emergence of dynamic structures and coherent dynamics, may be one of the key processes for living organisms to acquire complex structures and functions. A representative example of DSO in a living organism is coordinated behavior of migrating cells. Migratory behavior is a ubiquitous kind of eukaryotic cell dynamics. Some cells migrate on a substrate according to intracellular signals that localize at their front or back, even without extracellular cues. When migrating cells communicate with each other and act in union, they can exhibit varieties ofdynamic patterns and coherent motion. We are working on theoretical modeling and computational simulations of such single cellular migration [1,2] and multi-cellular behavior [3-6]. Here, we will mainly discuss what forms of DSO of migrating cells are caused through contact communication between cellstheoretically [5] and how such DSO could play functional roles. Firstly, our theoretical model based on an individual-celldynamics is extended to the multi-cellular situation in which migrating cells perform two ubiquitous types of contact communication, calledcontact following and contact inhibition of locomotion [5], and the simulation results of this model regarding DSO will be explained [5]. Comparisons of some simulation results with the experimental observations of social amoeba are also provided [4]. Lastly, how such DSO can play rolesfor functional behaviors, like accurate directional migration under directional cue, is discussed based on simulations of the variant model[5,6].

 

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[1] T. Hiraiwa, A. Nagamatsu et al., Physical Biology 11, 056002 (2014).

[2] T. Hiraiwa, A. Baba et al. Euro. Phys. J. E 36, 32 (2013).

[3] T. Hiraiwa, Physical Review E 99, 012614 (2019).

[4] M. Hayakawa, T. Hiraiwa et al., eLife 9, e53609 (2020).

[5] T. Hiraiwa, Physical Review Letters 125, 268104 (2020).

[6] T. Hiraiwa, Euro. Phys. J. E 45, 1 (2022).