Abstract

Large-scale cell death is widely observed during embryonic development and various human pathological conditions. However, a systems-level understanding for how large-scale cell death emerges had been lacking. Harnessing time-lapse imaging, chemical/genetic perturbations and mathematical modeling, we show how metabolic stress quantitatively modulate cellular state for the emergence of redox multistability, allowing reactive oxygen species (ROS) to regenerate and propagate across millions of cells. In a developing embryo, cell death propagation accompanies the massive, yet spatially restricted, cell death events observed during muscle remodeling of the embryonic avian limb. Together, our findings highlight the potential role of cell death propagation in coordinating global cell death events, providing a paradigm for investigating large-scale cell death in embryonic development and human pathologies.

 

WebEx Link: https://nationaltaiwanuniversity-ksz.my.webex.com/nationaltaiwanuniversity-ksz.my/j.php?MTID=m1b307152046781ef3970c0062014209a

Meeting number (access code): 2511 997 7890

Meeting password: FFrNCiBR862

 

Organizer: Tai-Chia Lin (NTU)